Secondo uno studio recente, presentato durante la Settimana del Rene (Kidney Week 2014), alla Società Americana di Nefrologia (ASN), presso il Pennsylvania Convention Center di Philadelphia, un gruppo di ricercatori ha esaminato e correttamente evidenziato l’associazione tra la perdita di peso ottenuta dal paziente obeso, dopo un intervento di chirurgia bariatrica e la velocità di filtrazione glomerulare (eGFR) , stimata attraverso l’equazione CKD-EPI.



“Bariatric surgery serves as a good model to examine the effects of weight loss on kidney function. Our findings suggest a beneficial impact on kidney function in patients with and without baseline kidney disease,” said Alex Chang from the Geisinger Medical Center, Pennsylvania.

The association between weight loss and resolution of albuminuria was examined in the subset of patients with baseline albuminuria (albumin/creatinine ratio >=30mg/g) and subsequent ACR quantification. Mixed effects models were used, adjusted for time and baseline weight, allowing intercepts and slopes to vary for each individual.

A total of 3,134 patients were followed for a median of 2.4 years and the mean age was 47.2, 36.6% had diabetes, and 6.4% had eGFR

They noted that every 5kg of weight loss was associated with a 0.50 ml/ min/1.73m2 (95% CI: 0.42 to 0.57; p<0.001) increase in eGFR. The association between weight loss and increased eGFR was stronger in patients with eGFR <60ml/min/1.73m2: 0.89 ml/min/1.73m2 per 5kg decrease (95% CI: 0.63 to 1.15; p<0.001) compared to 0.46 (0.39 to 0.54; p<0.001) for those with eGFR >60 ml/min/1.73m2 (p

“More emphasis should be placed on promoting healthy lifestyles to avoid morbid obesity, and prevent chronic kidney disease,” concluded Chang. “Additional studies using other markers of kidney function are needed to confirm the study’s findings and to examine the effect of weight loss on long-term kidney outcomes.”

Owen Haskins – Caporedattore, Bariatric News

Novembre 2014

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